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Published Work

The Fruits of Our Labor

25. Discovery of a potent GLUT inhibitor using rapafucin 3D microarrays. (Accepted) Angew. Chem. Int. Ed. Guo ZF#, Cheng Z#, Wang J#, Liu W, Peng H, Wang Y, Rao AVS, Li RJ, Ying X, Korangath P, Liberti MV, Li Y, Xie Y, Hong SY, Schiene-Fischer C, Fischer G, Locasale JW, Sukumar S, Zhu H, Liu JO. (# = co-first authors).

24. Rapafucins, rapamycin-inspired macrocycles with new target specificity. (2019) Nat. Chem.,11(3):254-63. Guo ZF#, Hong SY#, Wang J#, Rehan S, Liu W, Peng H, Das M, Li W, Bhat S, Peiffer B, Ullman BR, Tse CM, Tarmakova Z, Schiene-Fischer C, Fischer G, Coe I, Paavilainen VO, Sun Z, Liu JO. (# = co-first authors).

23. Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes. (2019) J. Vis. Exp.(143), e59021. Wang J, Hammond J, Johnson KA.

22. Mechanistic studies of a small molecule modulator of SMN2 splicing, PNAS, 115(20): E4604-12. (2018) Wang J, Schultz PG, Johnson K.

21. Oligoribonuclease is the primary degradative enzyme for pGpG in P. aeruginosa that is required for cyclic-di-GMP turnover. PNAS 112(36): E5048-57. (2015) Orr MW, Donaldson GP, Severin GB, Wang J, Sintim HO, Waters CM, Lee VT.

20. Essential roles of methionine and SAM in the autarkic lifestyle of Mycobacterium tuberculosis. PNAS 112(32): 10008-13. (2015) Berney M, Berney-Meyer L, Wong KW, Chen B, Chen M, Kim J, Wang J, Harris D, Parkhill J, Chan J, Wang F, Jacobs WR.

19. Octameric G8 c-di-GMP is an efficient peroxidase and this suggests that an open G-tetrad site can effectively enhance hemin peroxidation reactions. RSC Adv. 3(18): 6305-10. (2013) Roembke BT, Wang J, Nakayama S, Zhou J, Sintim HO.

18. Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2’-F-di-GMP, Bioorg. Med. Chem. 21(14), 4396-404. (2013) Zhou J, Watt S, Wang J, Nakayama S, Sayre DA, Lam YF, Lee VT, Sintim HO.

17. Selective binding of 2’-F-di-GMP to Ct-E88 and Cb-E43, new class I riboswitches from C. tetani and C. botulinum respectively. Mol. BioSys. 9(6): 1535-9. (2013) Luo Y, Zhou J, Wang J, Dayie K, Sintim HO.


16. Endo-S-di-GMP analogues-polymorphism and binding studies with class I riboswitch. Molecule 17(11): 13376-89. (2012). Zhou J, Sayre DA, Wang J, Pahadi N, Sintim HO. 


15. Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs. Future Med. Chem. 4(9):1113-51. (2012) Wang J, Hudson R, Sintim HO. 

14. Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues. ACS Chem. Biol. 7(6): 1023-30. (2012) Gamby S, Roy V, Guo M, Smith JAI, Wang J, Stewart JE, Wang X, Bentley WE, Sintim HO.

13. Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules. Biochemistry 50(32): 6983-93. (2011) Kamaraju K, Smith J, Wang J, Roy V, Sintim HO, Bentley WE, Sukharev S.

12. Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins. J. Am. Chem. Soc. 133(24):9320-90. (2011) Wang J, Zhou J, Donaldson GP, Nakayama S, Yan L, Lam YF, Lee VT, Sintim HO. 

11. Differential radial capillary action of ligand assay for HTS detection of protein-metabolite interactions. PNAS 108(37): 15528-33. (2011) Roelofs KG, Wang J, Sintim HO, Lee VT.


10. DNA-based peroxidation catalyst—What is the exact role of topology on catalysis and is there a special binding site for catalysis? Chem. Eur. J. 17(20): 5691-8. (2011) Nakayama S, Wang J, Sintim HO.

9. Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule. J. Am. Chem. Soc. 133(13):4856-64. (2011) Nakayama S, Kelsey I, Wang J, Roelofs K, Stefane B, Luo Y, Lee VT, Sintim HO.

8. C-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators. Chem. Commun. 47(16): 4766-8. (2011) Nakayama S, Kelsey I, Wang J, Sintim HO.

7. Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties. Chem. Eur. J. 17(12):3352-7. (2011) Wang J & Sintim HO. 


6. Synthetic analogs tailor native AI-2 signaling across bacterial species. J. Am. Chem. Soc. 132(32):11141-50.  (2010) Roy V, Smith JAI, Wang J, Stewart JE, Bentley WE, Sintim HO.

5. Remote C–H functionalization; using atom-economical tethers to switch between 1,5- and the rare 1,7-C–H insertions. Angew. Chem. Int. Ed. 49(23):3964-8. (2010) Wang J, Stefane B, Jaber D, Smith JA, Vickery C, Diop M, Sintim HO.


4. Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules. Future Med. Chem. 2(6):1005-35. (2010) Sintim HO, Smith JAI, Wang J, Nakayama S, Yan L.

3. Efforts towards the identification of simpler platensimycin analogs, the total synthesis of oxazinidinyl platensimycin. Chem. Eur. J. 15(12):2747-50. (2009) Wang J, Lee VT, Sintim HO.


2. Biological screening of a diverse set of AI-2 analogues in V. harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous. Chem. Commun. 45:7033-5. (2009) Smith JAI, Wang J, Nguyen-Mau SM, Lee VT, Sintim HO.

1. A computationally designed Rh(I)-catalyzed two-component [5+2+1] cycloaddition of ene-vinylcyclopropanes and CO for the synthesis of cyclo-octenones. J. Am. Chem. Soc. 129(33):10060-10061. (2007) Wang Y, Wang J, Su J, Huang F, Jiao L, Liang Y, Yang D, Zhang S, Wender PA, Yu ZX.